Skip to content
America's Blood Centers
  • About
    • About ABC
    • Leadership
    • Committees
    • ABC Strategic Plan
    • Partners
    • Career Center
    • Membership Directory
    • Women’s Executive Leadership Community
    • Foundation
    • ADRP
  • Advocacy
    • 2023 Advocacy Agenda
    • Our Priorities
      • Strengthening the Blood Supply
      • Modernizing the Licensure Process
      • Expanding Access to Blood Products
      • Moving Toward an Individual Donor Assessment
      • Diversifying the Donor Base
      • Eliminating Unnecessary and Duplicative Testing Requirements
      • Lowering the U.S. Platelet Content Requirement
      • Expanding the Availability of Blood in Hospice
      • Updating vCJD Guidance
    • Letters and Comments
    • Action Center
  • Events
    • Blood Advocacy Week
    • 2023 Awards of Excellence
    • All Upcoming Events
    • Sponsors
      • Sponsorship Opportunities
  • News
    • Press Releases
    • One-Pagers & FAQs
    • All Latest News
    • For Media
  • Publications
    • ABC Newsletter
    • Blood Bulletin
    • Grassroots Handbook
    • U.S. Blood Donation Statistics and Public Messaging Guide
    • Vein to Vein: The Science of Blood Donation
    • Blood Centers Career Video
    • ABC Benchmark Surveys
    • The Value of Blood
    • Advertise
    • Grant Funding Guide đź”’
  • For Members
    • CollABOrateđź”’
    • Recent Member Communications (MCNs)đź”’
    • Talking Pointsđź”’
    • Member Snapshot Survey Reportsđź”’
    • ABC Newsletter Archiveđź”’
    • Webinar Recordingsđź”’
      • Advocacy Webinarsđź”’
      • Donor Management Webinarsđź”’
      • Human Resources Webinarsđź”’
      • SMT Journal Club Webinarsđź”’
      • Quality Education Webinarsđź”’
    • Resources
    • Get Involved
    • Directory
  • For Donors
    • About Donation
    • Journey of Blood
    • Find a Blood Center
    • DonatingBlood.org
    • Current U.S. Blood Supply
  • HOSA Partners
  • Become an ABC Member
  • Member Login
America's Blood Centers
  • About
    • About ABC
    • Leadership
    • Committees
    • ABC Strategic Plan
    • Partners
    • Career Center
    • Membership Directory
    • Women’s Executive Leadership Community
    • Foundation
    • ADRP
  • Advocacy
    • 2023 Advocacy Agenda
    • Our Priorities
      • Strengthening the Blood Supply
      • Modernizing the Licensure Process
      • Expanding Access to Blood Products
      • Moving Toward an Individual Donor Assessment
      • Diversifying the Donor Base
      • Eliminating Unnecessary and Duplicative Testing Requirements
      • Lowering the U.S. Platelet Content Requirement
      • Expanding the Availability of Blood in Hospice
      • Updating vCJD Guidance
    • Letters and Comments
    • Action Center
  • Events
    • Blood Advocacy Week
    • 2023 Awards of Excellence
    • All Upcoming Events
    • Sponsors
      • Sponsorship Opportunities
  • News
    • Press Releases
    • One-Pagers & FAQs
    • All Latest News
    • For Media
  • Publications
    • ABC Newsletter
    • Blood Bulletin
    • Grassroots Handbook
    • U.S. Blood Donation Statistics and Public Messaging Guide
    • Vein to Vein: The Science of Blood Donation
    • Blood Centers Career Video
    • ABC Benchmark Surveys
    • The Value of Blood
    • Advertise
    • Grant Funding Guide đź”’
  • For Members
    • CollABOrateđź”’
    • Recent Member Communications (MCNs)đź”’
    • Talking Pointsđź”’
    • Member Snapshot Survey Reportsđź”’
    • ABC Newsletter Archiveđź”’
    • Webinar Recordingsđź”’
      • Advocacy Webinarsđź”’
      • Donor Management Webinarsđź”’
      • Human Resources Webinarsđź”’
      • SMT Journal Club Webinarsđź”’
      • Quality Education Webinarsđź”’
    • Resources
    • Get Involved
    • Directory
  • For Donors
    • About Donation
    • Journey of Blood
    • Find a Blood Center
    • DonatingBlood.org
    • Current U.S. Blood Supply
September 9, 2022

Phase I In-human Trial of Potential RBC Substitute Reported

By America's Blood Centers

A research letter authored by investigators in Japan has been published in Blood Advances reporting on the first-in-human phase I clinical trial of hemoglobin-vesicles (HbVs) developed as a transfusion alternative. The researchers explained that hemoglobin-based oxygen carriers (HBOCs) “can be useful because they are pathogen-free, blood-type-free, and capable of long-term preservation.” HBOCs are chemical entities designed to provide an alternative to red blood cell transfusion in a variety of clinical settings.

For this trial, the authors have developed and used an alternative to first-generation HBOCs. These have been known to “entail statistically higher risks of myocardial infarction and death in the clinical trials [presumably] related to their small molecular sizes, high intrinsic affinities to nitric oxide (NO), and their acellular structure, which collectively cause extravasation, vasoconstriction, hypertension, and oxidative lesion.”

Subscribe to the ABC Newsletter for the full story and more.
Posted in ABC Newsletter
Share this

Recent Posts

  • Frequently Asked Questions about the FDA’s Move to Individual Donor Assessments
  • 2021 NBCUS Supplemental Data Published
  • Group O Whole Blood in Military Ground Ambulances
  • Promoting Awareness of New Eligibility Criteria
  • Expanding Access to Blood Products

Categories

  • ABC Newsletter
  • Blood Bulletin
  • Letters and Comments
  • News
  • One-Pagers and FAQs
  • Press Releases

Contact

abc-60-logo

1717 K Street NW, Suite 900
Washington, DC 20006

Tel: 202-393-5725

Fax: 202-899-2621

  • About
    • About ABC
    • Leadership
    • Committees
    • ABC Strategic Plan
    • Partners
    • Career Center
    • Membership Directory
    • Women’s Executive Leadership Community
    • Foundation
    • ADRP
  • Advocacy
    • 2023 Advocacy Agenda
    • Our Priorities
      • Strengthening the Blood Supply
      • Modernizing the Licensure Process
      • Expanding Access to Blood Products
      • Moving Toward an Individual Donor Assessment
      • Diversifying the Donor Base
      • Eliminating Unnecessary and Duplicative Testing Requirements
      • Lowering the U.S. Platelet Content Requirement
      • Expanding the Availability of Blood in Hospice
      • Updating vCJD Guidance
    • Letters and Comments
    • Action Center
  • Events
    • Blood Advocacy Week
    • 2023 Awards of Excellence
    • All Upcoming Events
    • Sponsors
      • Sponsorship Opportunities
  • News
    • Press Releases
    • One-Pagers & FAQs
    • All Latest News
    • For Media
  • Publications
    • ABC Newsletter
    • Blood Bulletin
    • Grassroots Handbook
    • U.S. Blood Donation Statistics and Public Messaging Guide
    • Vein to Vein: The Science of Blood Donation
    • Blood Centers Career Video
    • ABC Benchmark Surveys
    • The Value of Blood
    • Advertise
    • Grant Funding Guide đź”’
  • For Members
    • CollABOrateđź”’
    • Recent Member Communications (MCNs)đź”’
    • Talking Pointsđź”’
    • Member Snapshot Survey Reportsđź”’
    • ABC Newsletter Archiveđź”’
    • Webinar Recordingsđź”’
      • Advocacy Webinarsđź”’
      • Donor Management Webinarsđź”’
      • Human Resources Webinarsđź”’
      • SMT Journal Club Webinarsđź”’
      • Quality Education Webinarsđź”’
    • Resources
    • Get Involved
    • Directory
  • For Donors
    • About Donation
    • Journey of Blood
    • Find a Blood Center
    • DonatingBlood.org
    • Current U.S. Blood Supply
  • Sitemap
  • Privacy Policy
  • Terms of Use
Become a Member
Member Login

Copyright © 2023 © America's Blood Centers. All Rights Reserved.

Website by Yoko Co

Scroll To Top