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September 9, 2022

Phase I In-human Trial of Potential RBC Substitute Reported

By America's Blood Centers

A research letter authored by investigators in Japan has been published in Blood Advances reporting on the first-in-human phase I clinical trial of hemoglobin-vesicles (HbVs) developed as a transfusion alternative. The researchers explained that hemoglobin-based oxygen carriers (HBOCs) β€œcan be useful because they are pathogen-free, blood-type-free, and capable of long-term preservation.” HBOCs are chemical entities designed to provide an alternative to red blood cell transfusion in a variety of clinical settings.

For this trial, the authors have developed and used an alternative to first-generation HBOCs. These have been known to β€œentail statistically higher risks of myocardial infarction and death in the clinical trials [presumably] related to their small molecular sizes, high intrinsic affinities to nitric oxide (NO), and their acellular structure, which collectively cause extravasation, vasoconstriction, hypertension, and oxidative lesion.”

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  • About Us
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      • Stop the Bleed National Partnership
      • National Partnerships User Guide
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    • Priorities
      • Strengthening the Cyber Resilience of the Blood Community
      • Reducing Unnecessary Regulatory Burdens
      • Modernizing the Licensure Process
      • Exempt Blood Center LDTs from Diagnostic Regulation Reforms
      • Diversifying the Donor Base
      • Expanding the Use of Blood in Ambulances
      • Strengthening the Blood Supply
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