Skip to content
America's Blood Centers
  • About
    • Leadership
    • Committees
    • ABC Strategic Plan
    • Partners
    • Careers
    • Membership Directory
    • Foundation
    • ADRP
  • Advocacy
    • 2023 Advocacy Agenda
    • Reducing Unnecessary and Burdensome Regulation
    • Promoting a Robust Donor Base
    • Supporting the Vital Role of Blood in Healthcare
  • Events
    • 2023 Day on Capitol Hill
    • 2023 Awards of Excellence
    • ADRP Annual Conference
    • 2022 ABC MD Workshop and Summer Summit
    • Sponsors
      • Sponsorship Opportunities
  • News
    • Press Releases
    • For Media
    • Letters and Comments
    • Advocacy News
  • Publications
    • Blood Centers Career Video
    • The Value of Blood
    • Advertise
    • Vein to Vein: The Science of Blood Donation
    • U.S. Blood Donation Statistics and Public Messaging Guide
    • ABC Benchmark Surveys
    • Blood Bulletin
    • Grant Funding Guide đź”’
  • For Members
    • Member Login
    • Collaborate
    • Resources
    • Get Involved
    • Directory
  • For Donors
    • About Donation
    • Journey of Blood
    • Find a Blood Center
    • DonatingBlood.org
  • Foundation
  • DonatingBlood.org
  • ADRP
  • Collaborate
  • Member Login
America's Blood Centers
  • About
    • Leadership
    • Committees
    • ABC Strategic Plan
    • Partners
    • Careers
    • Membership Directory
    • Foundation
    • ADRP
  • Advocacy
    • 2023 Advocacy Agenda
    • Reducing Unnecessary and Burdensome Regulation
    • Promoting a Robust Donor Base
    • Supporting the Vital Role of Blood in Healthcare
  • Events
    • 2023 Day on Capitol Hill
    • 2023 Awards of Excellence
    • ADRP Annual Conference
    • 2022 ABC MD Workshop and Summer Summit
    • Sponsors
      • Sponsorship Opportunities
  • News
    • Press Releases
    • For Media
    • Letters and Comments
    • Advocacy News
  • Publications
    • Blood Centers Career Video
    • The Value of Blood
    • Advertise
    • Vein to Vein: The Science of Blood Donation
    • U.S. Blood Donation Statistics and Public Messaging Guide
    • ABC Benchmark Surveys
    • Blood Bulletin
    • Grant Funding Guide đź”’
  • For Members
    • Member Login
    • Collaborate
    • Resources
    • Get Involved
    • Directory
  • For Donors
    • About Donation
    • Journey of Blood
    • Find a Blood Center
    • DonatingBlood.org
September 9, 2022

Phase I In-human Trial of Potential RBC Substitute Reported

By America's Blood Centers

A research letter authored by investigators in Japan has been published in Blood Advances reporting on the first-in-human phase I clinical trial of hemoglobin-vesicles (HbVs) developed as a transfusion alternative. The researchers explained that hemoglobin-based oxygen carriers (HBOCs) “can be useful because they are pathogen-free, blood-type-free, and capable of long-term preservation.” HBOCs are chemical entities designed to provide an alternative to red blood cell transfusion in a variety of clinical settings.

For this trial, the authors have developed and used an alternative to first-generation HBOCs. These have been known to “entail statistically higher risks of myocardial infarction and death in the clinical trials [presumably] related to their small molecular sizes, high intrinsic affinities to nitric oxide (NO), and their acellular structure, which collectively cause extravasation, vasoconstriction, hypertension, and oxidative lesion.”

Subscribe to the ABC Newsletter for the full story and more.
Posted in ABC Newsletter
Share this

Recent Posts

  • America’s Blood Centers Recognizes National Excellence in Supporting Blood Donation and Strengthening the Blood Supply
  • America’s Blood Centers Proposes Supply Chain Solutions to CBER
  • Blood Advocacy Week Begins April 24th
  • America’s Blood Centers Announces Jed Gorlin, MD, MBA Has Been Named Chief Medical Officer
  • Blood Community Committed to an Inclusive Blood Donation Process

Categories

  • ABC Newsletter
  • Blood Bulletin
  • Letters
  • News
  • Press Releases
  • Statements

Contact

abc-60-logo

1717 K Street NW, Suite 900
Washington, DC 20006

Tel: 202-393-5725

Fax: 202-899-2621

  • About
    • Leadership
    • Committees
    • ABC Strategic Plan
    • Partners
    • Careers
    • Membership Directory
    • Foundation
    • ADRP
  • Advocacy
    • 2023 Advocacy Agenda
    • Reducing Unnecessary and Burdensome Regulation
    • Promoting a Robust Donor Base
    • Supporting the Vital Role of Blood in Healthcare
  • Events
    • 2023 Day on Capitol Hill
    • 2023 Awards of Excellence
    • ADRP Annual Conference
    • 2022 ABC MD Workshop and Summer Summit
    • Sponsors
      • Sponsorship Opportunities
  • News
    • Press Releases
    • For Media
    • Letters and Comments
    • Advocacy News
  • Publications
    • Blood Centers Career Video
    • The Value of Blood
    • Advertise
    • Vein to Vein: The Science of Blood Donation
    • U.S. Blood Donation Statistics and Public Messaging Guide
    • ABC Benchmark Surveys
    • Blood Bulletin
    • Grant Funding Guide đź”’
  • For Members
    • Member Login
    • Collaborate
    • Resources
    • Get Involved
    • Directory
  • For Donors
    • About Donation
    • Journey of Blood
    • Find a Blood Center
    • DonatingBlood.org
  • Sitemap
  • Privacy Policy
  • Terms of Use
Become a Member
Member Login

Copyright © 2023 © America's Blood Centers. All Rights Reserved.

Website by Yoko Co

Scroll To Top