The leaders of America’s major blood organizations have penned this letter to Dr. Brian Christine, congratulating him on his recent appointment as Assistant Secretary of Health and requesting a meeting. America’s Blood Centers (ABC), the Association for the Advancement of Blood and Biotherapies (AABB), and the American Red Cross are eager to discuss their shared commitment to maintaining a safe and available national blood supply. This letter outlines key areas of collaboration they hope to address, including coordinating government activities on blood safety, participating in disaster response efforts, and supporting a national survey on blood collection and use. By reaching out promptly following Dr. Christine’s appointment, these organizations are proactively ensuring continued federal partnership in sustaining the nation’s critical blood supply. This letter offers a glimpse into the collaborative efforts that keep America’s healthcare system supplied with life-saving blood products.